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Packaging Your order will be packed safely and secure and dispatched within 24 hours. Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding. Serotonin release by platelets plays an generic Celebrex 200 mg Online Canada role in hemostasis. In two studies in healthy volunteers, and in patients with osteoarthritis and established heart disease respectively, celecoxib 200-400 mg daily has demonstrated a lack of interference with the cardioprotective antiplatelet effect of aspirin 100-325 mg.

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In vitro studies indicate that celecoxib, although not a substrate, is an inhibitor of CYP2D6. However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment.

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